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  • Writer's pictureLast Bench Pharmacist

B Pharm Medicinal Chemistry 2 pdf Notes

Updated: Feb 15

Yo, fellow B.Pharm backbenchers! Remember the good ol' days of Organic Chemistry, where the only thing longer than the carbon chains were your sighs of despair? Well, buckle up, because Medicinal Chemistry 2 is here to take the complexity crown (and your sanity) with a vengeance. But hey, at least with these B Pharm Medicinal Chemistry 2 pdf Notes, you won't have to suffer through lectures that sound like a robot trying to rap about photosynthesis. Consider this your cheat sheet to surviving the drug-induced madness of this semester, a secret decoder ring for the hieroglyphics of mechanisms, and a lifeline for your GPA. Just don't blame me if you start seeing ibuprofen bailando in your sleep – that's just the side effects of knowledge, baby.

(P.S. Don't ask me where I got these notes. Let's just say my sources are as shady as a molecule with five nitrile groups.)

B Pharm Medicinal Chemistry 2 Notes
B Pharm Medicinal Chemistry 2 Notes


This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class

Objectives: Upon completion of the subject student shall be able to:

  • Understand the chemistry of drugs with respect to their pharmacological activity

  • Understand the drug metabolic pathways, adverse effect and therapeutic value of drugs

  • Know the Structural Activity Relationship of different class of drugs

  • Study the chemical synthesis of selected drugs

B Pharm Medicinal Chemistry 2 pdf Notes

Unit 1

Chapter 1 (Antihistaminic agents)

Antihistaminic agents: Histamine, receptors and their distribution in the human body

  • H1–antagonists:Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine tartarate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium

  • H2-antagonists:Cimetidine*, Famotidine, Ranitidin.

Chapter 2 (Gastric Proton pump inhibitors)

Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole

Chapter 3 (Anti-neoplastic agents)

  • Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan, 107 Chlorambucil, Busulfan, Thiotepa

  • Antimetabolites: Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*,

  • Azathioprine Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin

  • Plant products: Etoposide, Vinblastin sulphate, Vincristin sulphate Miscellaneous: Cisplatin, Mitotane.

Unit 2

Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate, Isosorbide dinitrite*, Dipyridamole.

Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.


  • Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide.

  • Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide

  • Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid. Potassium sparing

  • Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics: Mannitol

Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.

Unit 3

Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.

Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine and Cholestipol

Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel

Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan.

Unit 4

Drugs acting on Endocrine system

Nomenclature, Stereochemistry and metabolism of steroids

Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol.

Drugs for erectile dysfunction: Sildenafil, Tadalafil. Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol

Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone

Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole.

Unit 5

Antidiabetic agents:

  • Insulin and its preparations

  • Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride.

  • Biguanides: Metformin.

  • Thiazolidinediones: Pioglitazone, Rosiglitazone. Meglitinides: Repaglinide, Nateglinide.

  • Glucosidase inhibitors: Acrabose, Voglibose.

Local Anesthetics: SAR of Local anesthetics

Benzoic Acid derivatives: Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine.

Amino Benzoic acid derivatives: Benzocaine*, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate.

Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine. Miscellaneous: Phenacaine, Diperodon, Dibucaine.*

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