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B Pharm Medicinal Chemistry Unit 3 Pdf Notes

Updated: Feb 15


B. Pharm Medicinal Chemistry Unit 3 takes you on a thrilling journey into the realm of parasympathomimetic agents, where drugs mimic the actions of the neurotransmitter acetylcholine, slowing down the heart, stimulating digestion, and promoting relaxation. Feeling lost in the labyrinth of receptors, mechanisms of action, and diverse therapeutic uses? Fear not, for we have a potent elixir to unlock these secrets – B. Pharm Medicinal Chemistry Unit 3 PDF notes.


B Pharm Medicinal Chemistry Notes
B Pharm Medicinal Chemistry Notes

B Pharm Medicinal Chemistry Unit 3 Pdf Notes


Unit 3


Chapter 1 (Parasympathomimetic Agents)

Cholinergic neurotransmitters: Biosynthesis and catabolism of acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.


Parasympathomimetic agents: SAR of Parasympathomimetic agents Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.


Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.


Cholinesterase reactivator: Pralidoxime chloride. Cholinergic Blocking agents: SAR of cholinolytic agents Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.


Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.



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