B Pharm Novel Drug Delivery System PDF Notes
B-Pharmers, unlock the future of medicine with B Pharm Novel Drug Delivery System (NDDS) PDF Notes in this exciting unit! Imagine designing medications that are more targeted, effective, and easier to use. Buckle up as we explore controlled-release systems, nanoparticles, liposomes, and more, revolutionizing how drugs are delivered. We'll delve into the science behind these innovative technologies, understanding how they can overcome challenges like poor bioavailability and frequent dosing. Get ready to see drugs delivered directly to their targets, reducing side effects and improving patient outcomes. NDDS isn't just science; it's about improving people's lives. By the end of this unit, you'll be equipped to contribute to the development of game-changing drug delivery systems, shaping the future of healthcare!
Scope
This subject is designed to impart basic knowledge on the area of novel drug delivery systems
Objectives:-
Upon completion of the subject student shall be able to
To understand various approaches for development of novel drug delivery systems.
To understand the criteria for selection of drugs and polymers for the development of Novel drug delivery systems, their formulation and evaluation
B Pharm Novel Drug Delivery System PDF Notes
Unit 1
Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations
Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems
Unit 2
Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications
Mucosal Drug Delivery system: Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems Implantable
Drug Delivery Systems: Introduction, advantages and disadvantages, concept of implantsand osmotic pump
Unit 3
Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications
Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers
Unit 4
Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications
Unit 5
Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts
Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications