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B Pharm Pharmaceutical Organic Chemistry 2 Pdf Notes

Updated: Feb 13

Organic chemistry can be a daunting beast, but fear not, Last Bench Pharmacists! B.Pharm Pharmaceutical Organic Chemistry 2 Notes are your secret weapon. Dive into the fascinating world of aromatic compounds, delve into the mysteries of fats and oils, and conquer the intricate realm of polynuclear hydrocarbons. These notes are your roadmap to mastering the reactions, mechanisms, and applications that fuel the pharmaceutical industry. Get ready to unlock the secrets of organic chemistry and watch your confidence soar!

B Pharm Pharmaceutical Organic Chemistry 2 Notes
B Pharm Pharmaceutical Organic Chemistry 2 Notes

Scope: This subject deals with general methods of preparation and reactions of some organic compounds. Reactivity of organic compounds are also studied here. The syllabus emphasizes on mechanisms and orientation of reactions. Chemistry of fats and oils are also included in the syllabus.

Objectives: Upon completion of the course the student shall be able to

1. write the structure, name and the type of isomerism of the organic compound 2. write the reaction, name the reaction and orientation of reactions

3. account for reactivity/stability of compounds,

4. prepare organic compounds

B Pharm Pharmaceutical Organic Chemistry 2 Pdf Notes

Unit 1

Chapter 1 (Benzene and its derivatives)

Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule

Reactions of benzene - nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.

Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction

Structure and uses of DDT, Saccharin, BHC and Chloramine

Unit 2

Chapter 1

Phenols* - Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols

Chapter 2

Aromatic Amines* - Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts

Chapter 3

Aromatic Acids* –Acidity, effect of substituents on acidity and important reactions of benzoic acid.

Unit 3

Chapter 1 (Fats and Oils)

Fatty acids – reactions.

Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.

Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.

Unit 4

Chapter 1 (Polynuclear hydrocarbons)

Synthesis, reactions

Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

Unit 5

Chapter 1 (Cyclo alkanes*)

Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

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