B Pharm Pharmaceutical Analysis Pdf Notes
Updated: Mar 16
B.Pharm students, are you ready to unlock the secrets of drug analysis? This crucial subject equips you with the skills to evaluate the quality, purity, and potency of medications, ensuring their safety and effectiveness. But navigating a sea of complex information can be daunting. Fear not, aspiring pharmaceutical analysts! Here's your treasure map to conquering this subject: free, downloadable B Pharm Pharmaceutical Analysis Pdf Notes!
Scope:
This course deals with the fundamentals of analytical chemistry and principles of electrochemical analysis of drugs
Objectives:
Upon completion of the course student shall be able to
Understand the principles of volumetric and electro chemical analysis
Carryout various volumetric and electrochemical titrations
Develop analytical skills
B Pharm Pharmaceutical Analysis Pdf Notes For Free
Unit 1
Pharmaceutical analysis
Definition and scope
Methods of expressing concentration
Primary and secondary standards.
Preparation and standardization of various molar and normal solutions- Oxalic acid, sodium hydroxide, hydrochloric acid, sodium thiosulphate, sulphuric acid, potassium permanganate and ceric ammonium sulphate
Errors: Sources of errors, types of errors, methods of minimizing errors, accuracy, precision and significant figures
Pharmacopoeia, Sources of impurities in medicinal agents, limit tests.
Unit 2
Acid base titration: Theories of acid base indicators, classification of acid base titrations and theory involved in titrations of strong, weak, and very weak acids and bases, neutralization curves.
Non aqueous titration: Solvents, acidimetry and alkalimetry titration and estimation of Sodium benzoate and Ephedrine HCl.
Unit 3
Precipitation titrations: Mohr’s method, Volhard’s, Modified Volhard’s, Fajans method, estimation of sodium chloride.
Complexometric titration: Classification, metal ion indicators, masking and demasking reagents, estimation of Magnesium sulphate, and calcium gluconate.
Gravimetry: Principle and steps involved in gravimetric analysis. Purity of the precipitate: co-precipitation and post precipitation, Estimation of barium sulphate.
Basic Principles, methods and application of diazotisation titration. Estimation of sodium nitrite and sodium nitrate.
Unit 4
Redox titrations
Concepts of oxidation and reduction
Types of redox titrations (Principles and applications)
Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry, Titration with potassium iodate
Unit 5
Electrochemical methods of analysis
Conductometry - Introduction, Conductivity cell, Conductometric titrations, applications.
Potentiometry - Electrochemical cell, construction and working of reference (Standard hydrogen, silver chloride electrode and calomel electrode) and indicator electrodes (metal electrodes and glass electrode), methods to determine end point of potentiometric titration and applications.
Polarography - Principle, Ilkovic equation, construction and working of dropping mercury electrode and rotating platinum electrode, applications.